The PAR-1 serine/threonine kinase regulates epithelial detachment and directional protrusion of migrating border cells
نویسندگان
چکیده
Background—Many cells that migrate during normal embryonic development or in metastatic cancer first detach from an epithelium. However, this step is often difficult to observe directly in vivo and the mechanisms controlling the ability of cells to leave the epithelium are poorly understood. In addition, once cells detach, they must assume a migratory phenotype, involving changes in cytoskeletal and signaling dynamics. Drosophila border cells provide a model system in which forward genetics and live cell imaging can be combined to investigate the cellular and molecular mechanisms of epithelial cell detachment and migration in vivo.
منابع مشابه
PAR-1 Kinase Regulates Epithelial Detachment and Directional Protrusion of Migrating Border Cells
BACKGROUND Many cells that migrate during normal embryonic development or in metastatic cancer first detach from an epithelium. However, this step is often difficult to observe directly in vivo, and the mechanisms controlling the ability of cells to leave the epithelium are poorly understood. In addition, once cells detach, they must assume a migratory phenotype, involving changes in cytoskelet...
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